Marshall University researchers to study healing


HUNTINGTON, W.Va. – A new study conducted at the Joan C. Edwards School of Medicine at Marshall University will investigate the health risks during pregnancy for women with both obesity-associated metabolic syndrome (MetS) and obesity-associated metabolic syndrome (MetS). substance use disorder.

Led by researchers from the Joan C. Edwards School of Medicine, Usha Murughiyan, MD, assistant professor of medicine, and Subha Arthur, Ph.D., associate professor of clinical and translational sciences, the project will identify health complications and women’s modifiable risk factors. with MetS and Substance Use Disorders to identify interventions that improve maternal health and reduce pregnancy-related complications.

The study will be funded by a $ 296,000 grant from the National Institutes of Health (NIH) (3P20GM121299-04S1) from the Office of Women’s Health Research at the National Institute of General Medical Sciences. Researchers will assess more than a decade of data from Marshall University’s Translational Science Core Data Warehouse, a research data repository that provides a single, secure, and managed distribution point for human subject data to use in the field. university research, to identify a unique cohort of women. with MetS and substance use disorders. The research team will then use the data to identify maternal complications, define associated socio-economic demographics, and identify modifiable conditions that can be addressed prospectively in a future proposal to improve maternal health.

“Translational research is about using data to identify opportunities for intervention or improvement, which means it has a very direct application in daily life,” said Murughiyan, who is also associate dean for research. clinic and medical director of the Marshall Clinical Research Center. “The goal of this study is of particular importance to West Virginia and the Appalachians as we work to proactively implement interventions to improve the health of pregnant women with metabolic syndrome and related disorders. to the use of substances. “

MetS is the most common complication of obesity. These are abdominal obesity, dyslipidemia, hypertension and diabetes which are commonly linked to other diseases such as cardiovascular and cerebrovascular disease and certain cancers. MetS also increases the risk of developing gestational diabetes mellitus (GDM) and preeclampsia (PE). Likewise, substance use disorders during pregnancy significantly increase the risk of maternal syphilis, gonorrhea, hepatitis, HIV, placental abruption and psychiatric disorders in children.

“By analyzing the data in our warehouse, we can determine how different MetS factors, such as insulin resistance, hypertension and dyslipidemia, individually or in combination, impact the risk of maternal morbidity in patients. pregnant women with substance use disorders, ”Arthur mentioned. “This approach will allow us to identify modifiable variables that can be proactively modified to improve health outcomes in pregnant women. “

This project is part of additional funding through the Centers of Excellence in Biomedical Research (COBRE) Appalachian Center for Cellular transport in Obesity Related Disorders (ACCORD) program. At Marshall University, COBRE ACCORD funds are used to support entry-level researchers and improve their ability to compete independently for NIH-funded research grants, as well as to establish science hubs to improve research infrastructure at Marshall.

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