A review of the relative contributions of methamphetamine use, depression, and risky sexual behaviors on rectal gonorrhea / chlamydia in a cohort of men who have sex with men in Los Angeles, California

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Gender Transm Dis. October 12, 2021. doi: 10.1097 / OLQ.0000000000001568. Online ahead of print.

ABSTRACT

BACKGROUND: Methamphetamine use, risky sexual behavior, and depression contribute to continuing disparities in HIV and sexually transmitted infections (STIs) among men who have sex with men (MSM). The relative contributions of these longitudinal effects are not well understood.

METHODS: This analysis used visit-level data from a longitudinal cohort of MSM, half of whom are HIV-positive, in Los Angeles, California. From 08/2014 to 03/2020, participants made follow-up visits every 6 months and underwent rectal gonorrhea / chlamydia (GC / CT) screening tests and completed questionnaires including depressive symptoms, number of receptive anal intercourse partners (RAI) and methamphetamine. use. Pathway analysis with structural equation modeling using simultaneous and lagged covariates was used to identify the relative contributions of methamphetamine use and depression on RAI partner count and rectal GC / CT over time.

RESULTS: 557 MSM with up to 6 visits (3 years) were included for a total of 2437 observations. Methamphetamine use and depressive symptoms were positively associated with the number of RAI partners (β = 0.28, p

CONCLUSIONS: Factors and patterns that contribute to risk behaviors associated with rectal GC / CT may differ depending on HIV status. Our results demonstrate the importance of combined treatment and prevention efforts that link screening and treatment for stimulant use and depression with prevention and treatment of STIs.

PMID: 34654768 | DOI: 10.1097 / OLQ.0000000000001568


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